Étude translationnelle de l’influence de la présence d’un pair sur la consommation d’alcool et son substrat neurobiologique (ALCOSOCIO)
Résumé de soumission
Although it is a truism that drug addiction often develops in a social context, social factors did not receive much attention in the neurosciences of drug addiction, perhaps due to the lack of truly interdisciplinary research with the human and social sciences. It is only recently that animal studies of addiction have started to take into account the role of social factors, especially those that are immediately present at the time of drug exposure (proximal social factors), such as the presence of peers or social contact. There is however to date no direct study of these factors on neurobiological networks. The present project will use a translational approach to make several steps forward to the benefit of a more integrative approach. Team 1 has shown that the presence of a peer, or the playback of positive ultrasonic vocalizations, induces a decrease in cocaine intake in rats and a decrease in psychostimulant drugs intake in human drug users. Lesioning the STN has modulated this influence, suggesting an involvement of this cerebral structure in this phenomenon. In this project, experiments with a rat model of alcohol consumption will test the involvement of the subthalamic nucleus (STN) in the effects of peer presence (presence of familiar or unfamiliar conspecifics) or the influence of playback of positive or negative ultrasonic vocalizations during alcohol self-administration, using deep brain stimulation of the STN. Second, a functional MRI study will be performed with alcohol-dependent human users performing a behavioral task specifically chosen to involve the STN. This experiment should allow to visualize, in the STN and its network, modulations induced by cues associated with alcohol and the presence or not of an observing peer . Relying on one team from Aix-Marseille University associated with the CNRS and AP-HM (Marseille Public Hospital) and one team from Geneva (Team 2), this combination of multiple levels of analysis makes our integrative project unique in the study of alcohol addiction. The teams involved in this project do not just focus on the same object—addiction—using different levels of analysis. Instead, by relating conceptual, methodological and technical developments made about the role of proximal social factors in alcohol addiction, the present project offers a truly innovative and realistic approach to this major clinical and public health problem.
Synthèse finale du projet
Productions scientifiques et communications (Liste non exhaustive)
Liste des articles et communications écrites
1. – Terenzi Damiano, Simon Nicolas, Munyua Gachomba Michael Joe, de Peretti Jeanne-Laure, Nazarian Bruno, Sein Julien, Anton Jean-Luc, Grandjean Didier, Baunez Christelle# and Chaminade Thierry # (2024) Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: involvement of the STN evidenced through Functional RMI. Mol Psych Dec;29(12):3742-3751 ; doi: 10.1038/s41380-024-02637-y.. PMID: 38926543. https://www-nature-com.insb.bib.cnrs.fr/articles/s41380-024-02637-y ; hal-04741091v1
2. – Vignal Lucie #, Vielle Cassandre #, Williams Maya, Maurice Nicolas, Degoulet Mickael, Baunez Christelle (2024) Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and the possible negative influence of a peer presence. Psychopharmacology DOI: 10.1007/s00213-024-06532-w. hal-04492263v1
3. – “Social presence and optogenetic modulation of the subthalamic nucleus reverse escalated cocaine intake” Cassandre Vielle, Lucie Vignal*, Alix Tiran-Cappello, Mickael Degoulet, Nicolas Maurice, Cécile Brocard, Florence Pelletier, Yann Pelloux, Christelle Baunez; EBPS Workshop, Roma, Italy; 26-28 june 2022
4. – “Influence of vocal communication on cocaine and alcohol intake in the rat” Cassandre Vielle, Yann Pelloux, Christelle Baunez ; EBPS Workshop, Roma, Italy; 26-28 june 2022
5. – “Study of the influence of the presence of a peer on alcohol intake and its neurobiological substrate” Mehdi Sicre, Elodie Giorla, Mickael Degoulet, Christelle Baunez, FENS 2022, Paris; July 2022
6. – “Social presence and optogenetic modulation of the subthalamic nucleus reverse escalated cocaine intake” Cassandre Vielle*, Lucie Vignal, Alix Tiran-Cappello, Mickael Degoulet, Nicolas Maurice, Cécile Brocard, Florence Pelletier, Yann Pelloux, Christelle Baunez; FENS 2022, Paris; July 2022
7. – The influence of the presence of a peer on control of inhibition in cocaine users and its neural correlates, Damiano Terenzi, Michael Joe Munyua, Jeanne Laure de Peretti, Bruno Nazarian, Julien Sein, Jean-Luc Anton, Nicolas Simon, Didier Grandjean, Thierry Chaminade and Christelle Baunez; NeuroFrance, Lyon; 24-26 may 2023
8. – Subthalamic high-frequency deep brain stimulation reduces addiction-like alcohol use and suppresses the effect of the peer’s presence, L. Vignal*, C. Vielle, M. Williams, N. Maurice, M. Degoulet, C. Baunez; NeuroFrance, Lyon; 24-26 may 2023
9. – Subthalamic Nucleus Optogenetic Inhibition Reduces Motivation for Social Interactions L. Vignal, M. Bancilhon, F. Vinet , C. Melon, C. Vielle, Y. Pelloux, N. Maurice, C. Baunez FENS 2024 ; Vienna, Austria ; july 2024
10. – Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI. D Terenzi, N Simon, MJM Gachomba, JL De Peretti, B Nazarian, J Sein, JL Anton, D Grandjean, C Baunez, T Chaminade, FENS 2024, Vienna, Austria ; july 2024
Liste des séminaires ou colloques en rapport avec le projet financé auxquels vous avez participé et/ou que vous avez organisé durant la période concernée
- Séminaire invité : Université de Montréal (invitée par Anna-Noelle Samaha), Implication du noyau subthalamique dans la consommation de drogues et sa modulation par le contexte social ; 11 janvier 2022
- Workshop EBPS (European Behavioural Pharmacology Society), “Modeling the social context during drug intake in the rat: role of the subthalamic nucleus as neurobiological substrate”, C Baunez, invited speaker , Roma, Italy, 26-28 june 2022
- Mini-conference EBPS-EBBS-at FENS 2022, “The subthalamic nucleus: an unexpected guest in the reward circuit” C Baunez, invited speaker (last minute replacement), Paris July 2022
- ISBRA(International Society for Biomedical Research on Alcoholism) /ESBRA (European Society for Biomedical Research on Alcoholism) meeting, “Subthalamic nucleus deep brain stimulation to reduce alcohol intake? Role in the influence of social presence on drug intake?”, C. Baunez, invited speaker in a symposium; Cracow, Poland, 17-20 sept 2022
- Addiction 2022, “How direct social presence modulates drug intake and role of the subthalamic nucleus in this effect”, C. Baunez, invited speaker in a symposium, Villasimius, Italy sept 24-28 2022
- GDR Psychiatrie et Addiction, « Interactions sociales et addiction : données translationnelles » C Baunez, invited speaker, Paris, 5 décembre 2022
- Séminaire invité: Université de Genève (Invitée par Sami El Boustani), The presence of a peer can modulate drug intake: an influence under the subthalamic nucleus influence, 13 février 2023
- European Winter Conference on Brain Research (EWCBR) 2023, “The subthalamic nucleus: an unexpected guest in the reward circuit” C Baunez, speaker invitée, organisatrice de symposium, Les Diablerets (CH), march 2023
- TERENZI D, Chaminade T, Grandjean D, Simon N, Baunez C. European Winter Conference on Brain Research (EWBR), Les Diablerets, Switzerland, 4–11 March 2023. The influence of the presence of a peer on cocaine addiction and its neural correlates. D Terenzi invited speaker
- NeuroFrance, “The contribution of the Subthalamic nucleus in impulsivity & compulsivity” C Baunez invited speaker in a symposium, Lyon 24-26 May 2023
- 1st International Congress of the Deep Brain Stimulation society: 30th birthday of STN DBS, “DBS in animal models of addiction: The subthalamic nucleus as the best target” C Baunez, invited speaker, Grenoble, June 2023
- Journées Neurosciences Psychiatrie Neurologie, “Interactions sociales et prise de drogues : rôle du noyau subthalamique » C Baunez, invited speaker, Paris 29-30 juin 2023
- Computational Neuroscience Society Workshop, “The Subthalamic nucleus: a key structure where value is integrated and drives selection of action” C Baunez, invited speaker in a workshop;Leipzig (Germany), 15-19 july 2023
- TERENZI D, Chaminade T, Grandjean D, Simon N, Baunez C. 14th Scientific Day of the MRI-INT Centre: « Neuroimaging beyond the cortex », 14 October 2023. Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: Involvement of the STN Evidenced Through Functional MRI. D Terenzi invited speaker
- TERENZI D, Chaminade T, Grandjean D, Simon N, Baunez C. Forum GDR CNRS 3557 Psychiatrie et Addiction, Paris, France, 9 November 2023. Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: Involvement of the STN Evidenced Through Functional MRI. D Terenzi invited speaker
- Séminaire invité: Univ Sussex, Brighton, UK (Invitée par Brian Singer) How social presence modulates drug intake and role of the subthalamic nucleus in this effect, 5th February 2024
- 8th World Congress of the World Association of Dual Disorders (WADD) and the 26th Congress of the Spanish Society of Dual Disorders (SEPD), “Regulation of cocaine and alcohol intake by either social context or subthalamic nucleus manipulation C Baunez, invited speaker in a symposium, Palma de Mallorca, Spain, April 2024
- TERENZI D, Chaminade T, Grandjean D, Simon N, Baunez C. European Society of Cognitive and Affective Neuroscience (ESCAN), Ghent, Belgium, 22–25 May 2024. Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: Involvement of the STN Evidenced Through Functional MRI. D Terenzi invited speaker
- TERENZI D, Chaminade T, Grandjean D, Simon N, Baunez C. Journées Neurosciences Psychiatrie Neurologie, Paris, France, 13–14 June 2024. Social Context and Drug Cues Modulate Inhibitory Control in Cocaine Addiction: Involvement of the STN Evidenced Through Functional MRI. D Terenzi invited speaker
- Séminaire invité: Univ Louvain Brussels (Invitée par Philippe De Timary), How social presence modulates drug intake and role of the subthalamic nucleus in this effect, 10th July 2024
- ISBRA, “Influence of the presence of peers on cocaine and alcohol consumption in rats and humans and role of the subthalamic nucleus: prospective therapeutic use of social context manipulations and deep brain stimulation” C Baunez, speaker invitée, organisatrice du symposium, Melbourne Australia 23-26 september 2024
- Séminaire invité: Lab for the neural circuitry of learning, Riken, Japan (invited by Joshua Johansen), How social presence modulates drug intake and role of the subthalamic nucleus in this effect, 30th October 2024
Communications au grand public
- Emission de radio CQFD, Radio Suisse https://www.rts.ch/la-1ere/programmes/cqfd/12498719-rencontre-avec-christelle-baunez-une-specialiste-des-circuits-de-la-recompense-01-10-2021.html?mediaShare=1
- Conférence grand Public NEUROSTORIES « Emprise de tête » « Addiction : drogue et influence d’autrui», Théâtre de L’olivier, Marseille, 24 novembre 2022 ; visible sur YouTube : Neurostories 2022 – Emprise de tête – Addiction : drogue et influence d’autrui (Christelle Baunez)
https://www.youtube.com/watch?v=oKmhvKVnI5I&t=41s - Participation à Déclics (Dialogues Entre Chercheurs et Lycéens pour les Intéresser à la Construction des Savoirs) le 16/12/2021 comme Capitaine Declics au Lycée Marie Curie, Marseille 5è
39. 09/12/2022 Capitaine Declics au Lycée Provence, Marseille - Conférence grand public pour l’association « Les sentiers de la connaissance », « Traiter certaines maladies du cerveau avec l’électricité », Salle des fêtes d’Allauch 2023, 6 avril 2023
- Conférence pour l’association « Rayonnement du CNRS » ; « Comment la présence d’autrui peut réguler la consommation de drogues ? », Campus Joseph-Aiguier, CNRS Marseille, 9 mai 2023
- Capitaine Declics en novembre 2023 au Lycée J Perrin, Marseille
- Brain Innovation Days, Oratrice invitée par European Brain Council « From rats to men: the influence of the social context on drug consumption, Bruxelles 13-14 novembre 2024
Equipes du projet
Coordonnateur :
BAUNEZ Christelle
N° ORCID : 0000-0002-4368-652X
Structure administrative de rattachement : CNRS
Laboratoire ou équipe : Institut de Neurosciences de la Timone, UMR7289, équipe BAGAMORE
Autres équipes participantes :
Responsable de l'équipe 2 : GRANDJEAN Didier
University of Geneva - Neuroscience of Emotion and Affective Dynamics Lab, FPSE, Swiss Center for Affective Scienc
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